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KMID : 0369820060360020097
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Jorunal of Korean Pharmaceutical Sciences
2006 Volume.36 No. 2 p.97 ~ p.102
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In Vitro Study of Transdermal Delivery System for Caffein in Slim Patch Type
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김정수/Kim JS
권동환/임도형/김구서/강진양/Kwon DH/Lim DH/Kim GS/Kang CY
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Abstract
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The aim of this study was to investigate the feasibility and optimize permeability of slim patch type as a transdermal delivery system of caffein. Slim patch type was formulated and tested in modified Franz diffusion cell across cellulose membrane and hairless mouse skin in pH 5.8 phosphate buffer solution (PBS). The effect of Pharmsolv® and drug concentration on permeation at four model, 1,2% Pharmsolv® with 0.12mg/cm2 caffein and 0.12, 1.2mg/cm2 caffein with 2% Pharmsolv® through hairless mouse skin was studied in vitro. The release of caffein from slim patch with various loading was fitted by the Higuchi's diffusion equation. The result showed that chemical Pharmsolv® produced a large and significant increase of permeation. The effect of 2% Pharmsolv® on permeation of caffein was greater about 10-fold greater than 1% Pharmsolv® in first 60 minutes. The effect of drug concentration, however, was lower than that produced by chemical Pharmsolv®. Within the tested system, the most efficient combination for caffein slim patch type was 0.12mg/cm2 caffein with 2% Pharmsolv®, although 1.2mg/cm2 caffein with 2% Pharmsolv® showed highest amounts permeation, because permeated percentages were significantly lower about 1/4∼1/5 times.
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KEYWORD
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Caffein, Slim patch, Transdermal delivery system, Pharmsolv(R), Modified Franz cell
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